Similar to myeloid hematologic disorders AML and myelodysplastic syndromes (MDS), BPDCN patients acquire somatic point mutations in TET2 and TP53, ASXL1, IDH2, NRAS, and NPM1, with TET2 truncating mutations being the most prevalent and recurrent genomic alteration reported9–12. The gene discussed is NPM1; the disease is acute myeloid leukemia.