Unsurprisingly, some have been associated with HCC, such as CD20 [13], PTTG1 [14], CDCA5 [15], HSP90AB1 [16], CCT3 [17], SF3B4 [16], SETDB1 [17], VPS45 [18], RACGAP1 [19], USP21 [20, 21], and KIF20A [22]. This evidence concerns the gene USP21 and hepatocellular carcinoma.