Besides regulating cytoprotective genes, Nrf2 induces the expression of metabolic genes, including glucose-6-phosphate dehydrogenase (G6PD), isocitrate dehydrogenase 1 (IDH1), phosphogluconate dehydrogenase (PGD), phosphoribosyl pyrophosphate amidotransferase (PPAT), methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), transketolase (TKT), and malic enzyme 1 (ME1) in non-small cell lung cancer (NSCLC) cells [20, 21]. The gene discussed is MTHFD2; the disease is non-small cell lung carcinoma.