Therefore, we hypothesize that any dysregulation of MKP-1 or Nrf2 in tumor cells activates the MKP-1/Nrf2 loop to keep the Nrf2-ARE system constitutively active, regulating the expression of genes involved in the PPP, generation of NAPDH, and synthesis of purine nucleotides. This evidence concerns the gene DUSP1 and neoplasm.