In contrast to previously published findings with other tumor models, we did not observe a significant difference in tumor growth in JAX mice (Additional file 2: Figure S2) compared to TAC mice (Fig. 4a) of untreated 9464D-GD2 tumors or tumors treated with RT alone or RT and combined 1⁄2 dose IT-IC, anti-CTLA-4, CpG, and anti-CD40. The gene discussed is CD40; the disease is neoplasm.