To determine whether a memory response was generated by the RT and combined 1⁄2 dose IT-IC, anti-CTLA-4, CpG, and anti-CD40 regimen, we rechallenged mice that achieved complete regression of their initial 9464D-GD2 tumor with the same tumor cells on the opposite flank on day 90 (Fig. 4c). The gene discussed is CD40; the disease is neoplasm.