Moreover, in recent studies, we show how the systemic administration of a DRD3 selective antagonist attenuated the neurodegeneration of the nigrostriatal pathway in two different mouse models of Parkinson’s disease, including the chronic intoxication with MPTP and probenecid and the stereotaxic administration of 6-hydroxydopamine [25, 31]. Here, DRD3 is linked to Parkinson disease.