We show here, using gene expression profiling of demyelinated and normal appearing grey matter from the motor cortex of secondary progressive MS cases with high and low levels of meningeal immune cell infiltrates, that at the RNA transcript level, there is a change in the balance of TNF signalling pathways from TNFR1/2-activated NFκB-dependent cell survival towards TNFR1 activated RIPK3 dependent necroptotic cell death with increasing levels and organisation of meningeal infiltration. The gene discussed is RIPK3; the disease is myeloid sarcoma.