TNF and myeloid sarcoma: Because the pathway analysis of all MS cases vs controls indicated an overrepresentation of pathways involving TNF/TNF receptor interaction and its many downstream signalling pathways (Fig. 2a), including cell death signalling, we decided to further analyse the expression of genes involved in TNF/TNFR1 and TNF/TNFR2 interactions, in preference to other significantly deregulated pathways.