To further explore the effect of TWS119 on post-stroke neural plasticity, the expression of GAP43 (a marker of post-stroke axonal, synaptic and glial plasticity), PSD95 (a marker for postsynaptic plasticity and synaptogenesis), Synaptophysin (a marker for presynaptic plasticity and synaptogenesis) and SMI312 (a marker of Neurofilament) in peri-infarct cortex were also quantified by immunohistochemistry at day 21 after stroke [4]. This evidence concerns the gene SYP and stroke disorder.