IFNG and Cerebral ischemia: Interestingly, CM co-treated with LPS plus IFN-γ and TWS119 significantly increased the formation of pro-angiogenic structures in OGD bEnd.3 cells (18.07 ± 2.12 versus 42.71 ± 4.98, P < 0.001), suggesting that the pro-angiogenic effect of TWS119 was likely attributed to modulating microglial polarization instead of the direct effect on vascular endothelial cells damaged by cerebral ischemia.