JPH2 and hydrops fetalis: Jph2 gene therapy in mice with HF was shown to normalize RyR2-induced calcium release, while β-adrenergic receptor blocker treatment improved TT integrity and Jph2 expression in mice after myocardial infarction (Reynolds et al. 2016; Fu et al. 2016; Lyon et al. 2012; Chen et al. 2012).