Preclinical models of HF have indicated that restoring TH function improves systolic and diastolic function with reduction in myocardial fibrosis and myocyte loss, with attenuation of adverse ventricular remodeling and increased resistance to arrhythmia induction (Rajagopalan et al. 2016; Weltman et al. 2014; Zhang et al. 2018). Here, TH is linked to hydrops fetalis.