CD8A and neoplasm: We hypothesize that several reasons might account for these observed findings: (1) the CD8/CD3 ratio is more appropriate to reflect the CD8+ TIL relative number, which may provide more actual insight into the functional impact of a CD8+ T cell; and (2) the quantitative balance between different subsets of TILs is also revealed by the immune cell ratio, which may be more reliable to indicate the immunologic response status on the tumour microenvironment.