In murine models of food allergy, oral exposure to antigen and an adjuvant stimulates gut epithelial cells to express the innate pro-allergenic IL-33, IL-25, and thymic stromal lymphopoietin (TSLP), which contribute to the development of acute reactions to food and promotion of Th2 response [1,6,7,8]. The gene discussed is IL33; the disease is food allergy.