CAIX in the murine mammary (4T1) adenocarcinoma is involved in the development of metastasis by the production of granulocyte colony secreted factor (G-CSF), which is stimulating the recruitment of bone marrow-derived cells (BMDC), including the immunomodulatory myeloid-derived suppressor cells (MDSCs) to the pre-metastatic niches [49]. This evidence concerns the gene CA9 and adenocarcinoma.