The mean mutated to total CALR mRNA ratio for del52 and ins5 mutants were, respectively, 62% and 61% in K562 cells, 60% and 55% in DAMI cells, 50% and 51% in UT-7 MPL cells, and 20% and 33% in TF-1 cells, as seen in Figure S1D, which represent values classically observed in CALR mutated MPN patients. This evidence concerns the gene CALR and myeloproliferative disorder.