CALR and myeloproliferative disorder: This showed that overexpression of EDEM1 selectively stabilized a del52 CALR/CANX complex, as seen in Figure 6D, whereas the overexpression of EDEM3 did not significantly impact on the formation of mutant CALR/CANX complexes, but increased the WT CALR/CANX complex, as seen in Figure 6E. These results show that the expression of CALR variants is dependent on a proximal ER quality control system, most likely including EDEM3, TXNDC11, and DNAJC10, which, when deregulated in MPN, might lead to sufficient stabilization of the proteins to yield constitutive MPL activation.