In accordance with the mechanism of CALR mutant degradation, we observed a significant deregulation of the expression of different ERAD components such as EDEM3, CANX, DNAJC10, SEL1L, VCP and different components of ubiquitin ligase complex in MPN samples, as seen in Figure 5E. The gene discussed is CALR; the disease is myeloproliferative neoplasm.