In accordance with the mechanism of CALR mutant degradation, we observed a significant deregulation of the expression of different ERAD components such as EDEM3, CANX, DNAJC10, SEL1L, VCP and different components of ubiquitin ligase complex in MPN samples, as seen in Figure 5E. This evidence concerns the gene EDEM3 and myeloproliferative neoplasm.