For upregulated lncRNAs, higher expression of lnc-CGRRF1-3:1; lnc-EIF2AK4-1:1, -1:4, and -1:5; lnc-GCH1-2:1, -2:2, and -2:3; lnc-IYD-2:1; lnc-TMEM206-6:1; and lnc-ULBP3-2:1 were associated with both lack of primary therapy outcome success and higher tumor grade, indicating the potential oncogenic roles of these lncRNAs in MIBC. Here, EIF2AK4 is linked to neoplasm.