For upregulated lncRNAs, higher expression of lnc-CGRRF1-3:1; lnc-EIF2AK4-1:1, -1:4, and -1:5; lnc-GCH1-2:1, -2:2, and -2:3; lnc-IYD-2:1; lnc-TMEM206-6:1; and lnc-ULBP3-2:1 were associated with both lack of primary therapy outcome success and higher tumor grade, indicating the potential oncogenic roles of these lncRNAs in MIBC. This evidence concerns the gene IYD and neoplasm.