TSC1 and urinary bladder cancer: The 20 lncRNAs are grouped into 12 sets with distinct expression patterns (lncRNAs adjacent to each other, such as lnc-EIF2AK4-1:1, lnc-EIF2AK4-1:4, and lnc-EIF2AK4-1:5, have the same expression pattern in nearly all patients), and their differential expression is visualized in Figure 1A. Although the expression of lncRNAs is low compared to that of protein-coding genes, their expressions ranges are still detectable and comparable to the expression ranges of some protein-coding genes implicated in bladder cancer, namely GSTM1, TSC1, HOXB2, NAT2, and APC (Supplementary Figure S1).