These 13 selected genes were previously described to be involved in OSCC [10,15,40] and were found to have a crucial role also in other malignancies such as for instance ZAP70 in chronic lymphocytic leukemia [41]; TERT in all the most common tumor types [42]; and FLI1 in Ewing sarcoma, rectal cancer and gastric cancer [43]. The gene discussed is FLI1; the disease is Ewing sarcoma.