F8 and hemophilia: Interestingly, however, hemophilia-related missense mutations around the unused N-glycosylation site N582 of coagulation factor VIII (FVIII) have been identified as promoting the N-glycosylation of the site by STT3B, thus impairing the secretion of the aberrantly glycosylated FVIII via, at least in part, the binding of the mutant protein to calreticulin [39,40].