Our results also indicate that PKDs that can be inhibited by Gö6976 (presumably PKD1 activated through the TLR/IL-1R signaling pathway) play a pivotal role in the development and progression of CIA and that successful inhibition of arthritis development with a PKD inhibitor at the early stage might be beneficial to delay (or halt) the progression of arthritis. Here, PRKD1 is linked to arthritic joint disease.