Because we found in our previous studies [17–21] that inhibition of PKD by Gö6976, but not inhibition of PKC by Gö6983, resulted in inhibition of TLR/IL-1R ligand-induced expression of proinflammatory mediators, we further investigated whether Gö6976 can suppress proinflammatory reactions in response to TLR/IL-1R ligands in HFLS-RA. The gene discussed is PRRT2; the disease is rheumatoid arthritis.