ACHE and hyperinsulinemic hypoglycemia, familial, 4: Indeed, vertebrate BChE has also been shown to have roles in (1) ACh hydrolysis in situations of AChE deficiency [63], (2) fat metabolism by hydrolyzing the feeding stimulant peptide octanoyl ghrelin [64], and (3) scavenging polyproline-rich peptides to regulate protein-protein and protein-DNA interactions [65].