HIF1A and viral infectious disease: Although the frequency of latency establishment shown by nested PCR of bulk splenocytes on day 16 (Fig 6A) was the same between wild type and HIF1αLoxP mice after MHV68-Cre virus infection, we found that the frequency of ex vivo reactivation of lytic virus from latently infected splenocytes was impaired in the absence of HIF1α (Fig 6B).