Fig 2A shows HIF1α protein expression is downregulated in Null MEFs at 24 hours of infection. Comparing virus titers in WT and Null cells inoculated with varying MOI, virus production was decreased uniformly in the absence of HIF1α. As shown in Fig 2B, time-course infection of Null cells at 5.0 MOI showed a slight reduction while a lower infection of 0.5 MOI had a significant decreased in virus production at later time-points. Here, HIF1A is linked to infection.