Since infection of mice with MHV68 provides a tractable animal model that manifests the fundamental strategies for gammaherpesvirus pathogenesis [31], we took advantage of genetic ablation of HIF1α in the HIF1αLoxP/LoxP mice by infection (Fig 5A) with a recombinant MHV68 virus encoding the Cre-recombinase protein under CMV promoter (MHV68-Cre) [40]. This evidence concerns the gene HIF1A and infection.