Our studies demonstrate that IL-22 not only prevents lung inflammation but also prevents gut leakage and maintains the integrity of the intestinal barrier to prevent other infections, the entry of dietary antigens into the circulation, pancreatic beta cell damage and insulin resistance in T2DM mice infected with Mtb. This defect in the lung enhances the susceptibility to Mtb infection, and in the colon, it allows bacteria to penetrate and induce systemic inflammation [43,70]. Here, IL22 is linked to Insulin resistance.