IL22 and type 2 diabetes mellitus: Histological analysis also revealed that the gut epithelial lining of T2DM and Mtb-infected T2DM mice was disintegrated compared with that of control and Mtb-infected mice, and further treatment of Mtb-infected T2DM mice with recombinant IL-22 (twice weekly) for 1 month prevented the gut epithelial cell lining damage (S13C Fig).