In a high-fat diet mouse model of T2DM, the impaired induction of IL-22 by CD4+ cells enhances susceptibility to infection by the intestinal pathogen Citrobacter rodentium [36] The intraperitoneal administration of IL‐22 significantly improve host mucosal defense and hyperglycemia and dyslipidemia in T2DM mice [36]. The gene discussed is CD4; the disease is type 2 diabetes mellitus.