Among lineage- cells, we were unable to detect any IL-22-producing type 1 innate lymphoid cells (ILC1) or type 2 innate lymphoid cells (ILC2) in various lymphoid organs of Mtb-infected control and T2DM mice at all three time points (one, three and five months after Mtb infection) (S2, S3A and S3B Figs) However, a significant number of lung and splenic ILC1s from Mtb-infected T2DM mice were positive for IFN-γ compared with those from the control Mtb-infected mice (S2, S3A and S4 Figs). This evidence concerns the gene IFNG and type 2 diabetes mellitus.