ELANE and infection: As shown in S11B Fig, in the lungs of Mtb-infected T2DM mice (6 months after infection), the epithelial cell lining in the proximity of the Ly6G+ cells was disintegrated (losing membrane integrity) compared with that in the lungs of control mice infected with Mtb. We found a significant increase in neutrophil elastase 2 levels in the lung homogenate of Mtb-infected T2DM mice compared to that of Mtb-infected control mice (S12B Fig).