We found that neutrophils from T2DM mice infected with Mtb produced more neutrophil elastase 2 (ELA2) than nondiabetic mice infected with Mtb. Recombinant IL-22 treatment and ILC3 transfer decreased the production of neutrophil ELA2 in the lungs of Mtb-infected T2DM mice. The gene discussed is ELANE; the disease is type 2 diabetes mellitus.