IL22 and infection: However, as shown in Fig 2C–2F, both subpopulations of IL-22-producing ILC3s were significantly reduced in the lungs and spleens of Mtb-infected T2DM mice compared with those of the Mtb-infected control mice at one, three and five months after infection (lung LTi+IL-22+ cells: 1 month, p<0.05; 3 months, p<0.001; and 5 months, p<0.001; Fig 2C.