We found that Mtb infection significantly increased the accumulation of lineage- and lineage+ IL-22 producing cells in the lung of control (lineage- cells: 0.18 ± 0.02 vs. 2.61 ± 0.08, p<0.01; lineage+ cells 0.36 ± 0.06 vs. 1.09 ± 0.05, p<0.01, Fig 2A) and T2DM mice (lineage- cells: 0.16 ± 0.02 vs. 0.85 ± 0.32, p<0.01; lineage+ cells: 0.09 ± 0.01 vs. 0.46 ± 0.03, p<0.01, Fig 2A). The gene discussed is IL22; the disease is type 2 diabetes mellitus.