TH and hyperinsulinemic hypoglycemia, familial, 4: Since impaired TH transport across BBs plays a major role in the neurological pathology in MCT8 deficiency, the aim of the present study is to identify alternative delivery routes that bypass the BBs in order to administer TH analogs that can exert thyromimetic actions on TH target neural cells and palliate the neurological symptoms present in MCT8-deficient patients.