The Ras/Raf/MEK/ERK signaling pathway is also associated with tumor angiogenesis, as is seen with toluhydroquinone (2-methyl-1,4-hydroquinone), a marine-derived fungi, which reduces HUVEC angiogenesis via the Ras/Raf/MEK/ERK cascade [39]. This evidence concerns the gene MAP2K7 and neoplasm.