As expected, silencing Mlxipl effectively down‐regulated the expression of its target genes including Fasn, Acaca, Elovl6, Scd1, Ptpn6 and Pnpla3 at 36 hours after Ad‐siMlxipl infection although their expression was restored to the control level at 72 hours (Figure 5D panels a and b). The gene discussed is PNPLA3; the disease is infection.