Although p.Phe508del(c.1521_1523delCTT), commonly known as ΔF508, is the most common pathogenic variantin CF patients, present in about 70% of CF alleles worldwide, the ones that causeamino acid substitutions correspond to almost 40% of CFTR variants(Cutting, 2015; Brennan and Schrijver, 2016). This evidence concerns the gene CFTR and cystic fibrosis.