For example, the lncRNAs ADAMTS9-AS2, HOTAIR and ZEB2-AS1 induce GC tumorigenesis through the phosphatidylinositol 3-kinase (PI3K)/AKT, NF-κB and Wnt/β-catenin signaling pathways, respectively [21–23]. This evidence concerns the gene AKT1 and gastric cancer.