For example, circ-ITCH [7], circHIPK3 [8] and circMTO1 [9] were all identified to have reduced levels in bladder cancer tissues and were negatively correlated with grading, staging, invasion, and lymph node metastasis of bladder cancer; circPRMT5 was significantly upregulated in serum and urine exosomes of bladder cancer patients and was statistically associated with tumor metastasis [6]. This evidence concerns the gene ITCH and neoplasm.