In addition, ciRS-7 has been reported to inhibit cancer growth by upregulating P21 [10], circELP3 promotes bladder cancer progression and drug resistance [12], circHIPK3 reduces lung metastasis by inhibiting heparanase expression [8], and circular RNA CEP128 promotes bladder cancer cell migration via MAPK signaling [11]. The gene discussed is HPSE; the disease is cancer.