JPT1 and breast carcinoma: Recent evidence has also shown that elevated JPT1 expression is directly correlated with poor prognosis in breast cancer patients.22 Further investigations revealed that JPT1 increases the migratory and invasive potential of breast cancer cells by upregulating the MYC oncogene and downstream effectors in vitro and further increases breast tumorigenesis in vivo.22 We, however, did not see any alterations in MYC protein abundance following silencing of JPT1 in EC cells (Figure 5).