It has been reported that PLCD1 restrains the proliferation, invasion, and migration of pancreatic cancer cells CAPAN‐1 and BXPC‐3, and induces apoptosis through cell cycle inhibition at the G0/G1 phase.48 The prognostic significance of PLCD1 in PDAC was not revealed through this investigation, but its role as a tumor suppressor gene in breast cancer, chronic myeloid leukemia, and colorectal cancer has been widely accepted.48, 49, 50, 51, 52, 53, 54, 55, 56, 57. The gene discussed is PLCD1; the disease is colorectal cancer.