CHI3L1 is liver‐enriched and non‐invasive biomarker used to stage and diagnoses substantial hepatic fibrosis.21 Together, the protein of COL‐4, α‐SMA, CTGF and TGF‐β (Figure 3B) and mRNA levels of Col‐4 (Figure 3C), TGF‐β (Figure 3D) and α‐SMA (Figure 3E) were all increased in liver tissues of AIH mice except mice treated with miRNA‐143. This evidence concerns the gene ACTA1 and Hepatic fibrosis.