The role of miRNA143 has been investigated in miRNA‐143/145‐/‐ mice, where it reported that several genes such as TGF‐β adaptor protein and disabled‐2 (DAB2) as well as the function of hematopoietic stem cells (HSC) were defected.30 Moreover, miRNA‐143 has been shown to regulate the NF‐κB and p38 MAPK pathways in CRC cells.31 Furthermore, miR‐143 level was decreased in patients with liver diseases especially liver fibrosis. The gene discussed is NFKB1; the disease is colorectal carcinoma.