However, one type of neuronal ceroid lipofuscinosis is different: CLN4 disease occurs when a patient inherits one mutant copy of the gene that encodes for a protein called CSPɑ, but the precise cellular dysfunction underlying CLN4 disease remains a mystery (Nosková et al., 2011; Benitez and Sands, 2017). The gene discussed is DNAJC5; the disease is infantile neuronal ceroid lipofuscinosis.