GBA1 and Parkinson disease: In a similar manner, Magalhaes et al proposed that in glucocerebrosidase (Gcase) deficient cells impaired ALR leads to a depletion of functional lysosomes capable of sustaining autophagic clearance of α‐synuclein.117 Of note, mutations in the glucocerebrosidase gene are causative for Gaucher disease (GD) the most common lysosomal storage disorders (LSD), and increase the risk of developing Parkinson disease.118, 119, 120