LYST and bacterial infectious disease: Nevertheless, data from LYST homologs in Drosophila melanogaster and Dictyostelium discoideum indicate that LYST might regulate organelle fusion.184, 185, 186 Unfortunately, the neurologic phenotypes displayed by LYST‐mutant mice were found to depend on genetic background.187 Nevertheless, the characterization of Lyst‐mutant beige mice indicated that LYST controls phagosomal maturation, triggered as a response to bacterial infection.