Higher prediagnostic total IgE has also been associated with decreased glioma risk,10 although one other study did not observe this association.27 A meta-analysis using a combination of studies of pre- and post-diagnostic sera identified that higher total IgE was associated with decreased risk, but that respiratory allergen-specific IgE was not,29 which is not in line with the findings of the current study as total IgE was not associated with glioma case–control status. The gene discussed is IGHE; the disease is central nervous system cancer.