IGHE and glioma: Higher prediagnostic total IgE has also been associated with decreased glioma risk,10 although one other study did not observe this association.27 A meta-analysis using a combination of studies of pre- and post-diagnostic sera identified that higher total IgE was associated with decreased risk, but that respiratory allergen-specific IgE was not,29 which is not in line with the findings of the current study as total IgE was not associated with glioma case–control status.