Similarly, Stelling et al. [92] manifested the suppressive function of the TGF-β/TGF-βR2/SMAD1/S1PR2 axis in DLBCL and showed that DLBCL cells have evolved to be able to inactivate the pathway at the SMAD1 expression level. The gene discussed is TGFBR2; the disease is diffuse large B-cell lymphoma.