Different studies have shown that PTPN14 modulates cell proliferation and invasion.32,33 In addition, a number of its nonfunctional mutations have been reported in breast, pancreas and colorectal tumours.34–36 In neuroblastoma, Schramm et al. have found a PTPN14 nonfunctional mutation in neuroblastoma relapse correlating with an aggressive phenotype.37 However, the biological functions of PTPN14 remain poorly characterised. Here, PTPN14 is linked to colorectal neoplasm.