CD274 and neoplasm: This finding is not surprising as HPV related OPSCC is considered in many aspects different from HPV- OPSCC and is known to have a better prognosis,34 more active anti-tumour immune response12 and favourable response to treatment.34 However, the nature of PD-L1+ spatial interactions in HPV+ OPSCC merits further investigation in larger cohorts, before their significance could be ruled out.