SNP rs72699833 is located on chromosome 1 and is associated in cis with PHGDH, a gene involved in the metabolism of serine that is overexpressed in some subtypes of breast, cervical, colorectal and non-small-cell lung cancer, and in these diseases generally associated with a poorer outcome.37–40. This evidence concerns the gene PHGDH and non-small cell lung carcinoma.