However, our current data indicate that chronic HIV-infection had profound effects on Panx-1 channel opening via an unknown mechanism that is independent of CD4, CXCR4 or CCR5 engagement for the virus, because soluble CD4, TAK779 or AMD3100 (Cat# SML0911, Cat# A5602, Sigma Chemical Co., St. The gene discussed is CXCR4; the disease is HIV infectious disease.