Nonetheless, the results from TOPARP-B have overall driven the design and conduct of several registration trials of PARP inhibitors in metastatic castration-resistant prostate cancer (NCT02987543, NCT02975934, and NCT03148795), which are likely to guide the clinical use of PARP inhibitors in metastatic prostate cancer in the future. The gene discussed is PARP1; the disease is metastatic prostate carcinoma.