S100A8 and melanoma: Long-term survivors, defined as patients who were still alive after 2.5 years, harbored a significantly lower median percentage of S100A8/A9 expressing cells than short-term survivors analyzing the primary melanoma tissue (TMA2: P = .015, TMA3: P < .0001) as well as analyzing metastatic tissue (TMA2: P = .00038, TMA3: P < .0001) (Fig. 3a and b).