Previous studies have shown that the TP53 signaling pathway is involved in inherited diseases with maxillofacial signs, such as Treacher Collins syndrome (TCS) or Acrofacial Dysostosis-Cincinnati type [27–29], neural stem cell apoptosis during embryonic development [30], and TP53-dependent apoptosis in neural progenitors in fn10a-mutated zebrafish [31]. This evidence concerns the gene TP53 and Treacher-Collins syndrome.