PTPRD and cancer: The PTP receptor-type D (PTPRD) gene is frequently inactivated by genetic (mutation, deletion, or copy number loss) or epigenetic (methylation) modifications in various human cancers, including head and neck squamous cell carcinoma (HNSCC) [9], lung cancer [10], cutaneous squamous cell carcinoma [11], glioblastoma [12], and malignant melanoma [13].