The discovery of NF-YAx mRNA in primary stage 2 and 3 NBs, its expression as the exclusive isoform in an advanced stage 3 NB, expression in stage E12.5 to E14.5 mouse embryos and induction by doxorubicin in NB cells, unveils a novel NF-YA splice mechanism and variant that is both regulated by and involved in NB, development and conditions of genotoxic-stress. The gene discussed is NFYA; the disease is neuroblastoma.