In mouse embryos, NF-YAx expression coincided with the reported phase of neurotrophin-regulated KIF1Bβ-dependent sympathetic neuroblast-culling, unrestrained NF-YAx expression induced KIF1Bβ-dependent necroptosis in neural-lineage progenitors and NB cells and association between doxorubicin-induced NF-YAx expression and necroptosis in NB cells, supports a pro-necroptotic cytotoxic function for NF-YAx and a potential role in KIF1Bβ-dependent suppression of NB initiation, during development. This evidence concerns the gene BDNF and neuroblastoma.