NFYA and neuroblastoma: Suboptimal NF-Y function in NB cells has also been implicated in de-regulating the matrix metalloproteinase and tissue inhibitor of metalloproteinase equilibrium, resulting in invasion [38] and increased expression of the NF-YA subunit has been reported to differentiate between aggressive stage 4 NBs and stage 4S NBs that exhibit spontaneous regression [39].