The results are displayed as box plots showing the correlation between CNV and methylation. With the SMART App, it is very interesting to observe that TRIM58 (cg04902327) shows a lower level of methylation with low-level copy number amplification, whereas other CpGs of TRIM58 show a positive correlation with CNV in lung squamous cell carcinoma (Fig. 3c, p value < 0.05). This evidence concerns the gene TRIM58 and squamous cell lung carcinoma.