The “Non-TT” variant type was associated with lower cumulative incidence of distant metastasis in the patients with tumor grade≦3 (HR 0.599, 95% CI 0.367–0.979, P = 0.041), microvascular invasion (HR 0.500, 95% CI 0.257–0.975, P = 0.042) and AFP >  26.5 ng/mL (HR 0.538; 95%CI 0.296–0.979, P = 0.043). The gene discussed is AFP; the disease is neoplasm.