While some proteins including ALDH1A1, ANXAs, CD14, LAMB1, LRP1, MAPK1, MFGE8, NFASC, NPTN, PDCD6IP, PRDXs, SELENBP1, and UBE2N were significantly increased or showed similar trends in subjects with HAND (ANI + MND + HAD) or ANI + MND compared to controls, a subset of proteins including CAPN1, CRMP1, LAMB2, RAB10, and CD163 were significantly increased only in the comparison of ANI + MND vs. controls. The gene discussed is CAPN1; the disease is mild neurocognitive disorder.