Multiple genes within the biological process of lipid biosynthetic process, including HMGCR, insulin-like growth factor binding protein 7 (IGFBP7), platelet-derived growth factor beta polypeptide (PDGFB), bone morphogenetic protein 6 (BMP6) were up-regulated, inferring synthesis of lipid was increased during the occurrence of NAFLD. Here, HMGCR is linked to metabolic dysfunction-associated steatotic liver disease.