The overexpression of CCN3 through lentiviral infection of MHCC97H cells in mice led to increased number of HSC with high expression of α-SMA, and the enhanced subcutaneous tumor growth was found in the MHCC97H-CCN3 group (0.74 ± 0.30 g vs. 1.43 ± 0.19 g p = 0.0308, Fig. 4d). This evidence concerns the gene ACTA1 and neoplasm.