In addition, biomarkers including the NLR, monocytes to lymphocytes ratio (MLR), platelets to lymphocytes (PLR), albumin (Alb), prognostic nutritional index (PNI), and systemic immune-inflammation index (SII) have been used frequently in glioma grading and prognosis in previous studies [11, 14]. The gene discussed is ALB; the disease is central nervous system cancer.