VEGFA and hereditary hemorrhagic telangiectasia: We then looked at circulating VEGF (vascular endothelial growth factor) concentrations, as these have previously been reported to be increased in HHT patients.26 However, circulating VEGF levels were similar in Eng-iKOe and control mice (Figure 4G) consistent with the idea that no systemic proangiogenic stimulus was present in Eng-iKOe adult mice.