Ninety-five percent of acute promyelocytic leukemia cases are associated with the t(15;17)(q22:q11) chromosomal translocation, which results in the fusion of the promyelocytic leukemia gene (PML) and the RARA gene, generating the fusion protein “PML-RARA” [24,25]. This evidence concerns the gene RARA and acute promyelocytic leukemia.