NFKB1 and colorectal carcinoma: In this study, we examined whether Calebin A has the necessary properties to modulate TNF-β-promoted malignancy of CRC cells through the modulation of proinflammatory transcription factor NF-κB signaling pathway and to determine, at least in part, the mechanisms of the Calebin A molecular signaling during carcinogenesis, because they are still poorly understood.