Additionally, 1 h pre-incubation with Calebin A, curcumin or BMS-345541, followed by TNF-β co-treatment, markedly reduced nuclear staining in all CRC cell lines: in HCT116 to 36%, 33% and 30%, in RKO to 42%, 41% and 36% and in SW480 to 43%, 42% and 35%. This evidence concerns the gene LTA and colorectal carcinoma.