In previous studies, our group could show that, in CRC cells, TNF-β activates the NF-κB signaling pathway, inducing cancer cell proliferation, invasion and up-regulating genes connected with metastasis, promotes epithelial-to-mesenchymal-transition, stimulates its own expression and further promotes expression of TNF-α [12,13]. The gene discussed is TNF; the disease is colorectal carcinoma.