LTA and neoplasm: We found, for the first time, that down-modulation of TNF-β-promoted transcription factor NF-κB activation and suppression of its nuclear translocation by Calebin A, and this was also inhibited in the same way by the knockdown of NF-κB on mRNA level using ASO-NF-κB, or on the IKK level by BMS-345541 (specific IKK-inhibitor) or by curcumin (natural inhibitor of NF-κB), may be essential mechanisms for Calebin A’s antitumorigenic potential in this inflammatory tumor environment.