Additionally, it has been previously shown that curcumin enhances the chemosensitivity of CRC to chemotherapeutics through regulation of MiR-34a and MiR-27a, activation of the MMR-repair system, influencing tumor–microenvironment cross-talk and suppression of NF-κB pathway activation [35,51,52,53,54]. This evidence concerns the gene NFKB1 and colorectal carcinoma.