Moreover, we have further demonstrated that NF-κB-specific biomarkers, which are linked to invasion (MMP-9), metastasis (CXCR4, Integrin β1), proliferation (Ki-67) and apoptosis (Caspase-3), were modulated by Calebin A. These findings indicate that Calebin A may act as a potent multitargeting anti-cancer agent and this effect is mediated partially through inhibiting NF-κB and NF-κB-promoted proteins in different CRC tumor cells. This evidence concerns the gene CXCR4 and neoplasm.